- The Short Answer: Reproductive Endocrinology & Infertility
- Why the Name Has Three Parts
- What an REI Subspecialist Actually Does
- The Training Path Behind the Acronym
- The Six Content Domains Under the Label
- The Two-Stage ABOG Exam
- What the 2025 Outcome Data Say
- Where REI Subspecialists Work
- Sequencing Your Preparation by Domain
- Frequently Asked Questions
- Here, REI means Reproductive Endocrinology & Infertility, an Ob/Gyn subspecialty certified through the American Board of Obstetrics and Gynecology (ABOG).
- Certification has two distinct stages: a written Qualifying Examination (QE) and an oral Certifying Examination (CE).
- ABOG's REI blueprint lists six primary categories and 27 subcategories, with no published percentage weights.
- Fellowship graduates from 2026 onward move from CE eligibility to QE eligibility; earlier graduates keep their prior requirements.
The Short Answer: Reproductive Endocrinology & Infertility
On this site, REI stands for Reproductive Endocrinology & Infertility. It is a subspecialty of obstetrics and gynecology focused on the hormonal regulation of reproduction, the evaluation and treatment of infertility, and the medical and surgical management of conditions that impair conception and early pregnancy. Physicians who complete the pathway are certified by the American Board of Obstetrics and Gynecology (ABOG).
The acronym is shared by other, unrelated credentials and organizations, so it is worth being precise. Everything on this page concerns the physician subspecialty and its ABOG certification, nothing else. If you want a broader orientation, our explainers on what REI is and the meaning of REI cover adjacent angles, and what REI certification involves goes deeper on the credential itself.
Why the Name Has Three Parts
Each word in the title points to a different strand of the discipline, and the exam reflects all three.
- Reproductive: the physiology of gametes, embryos, the endometrium, and early pregnancy, from folliculogenesis through implantation and the first trimester.
- Endocrinology: hormone structure and function, pharmacology, laboratory assays, and disorders of the hypothalamic-pituitary-ovarian axis, thyroid, and adrenal glands.
- Infertility: the clinical work of evaluating couples, treating ovulatory and tubal factors, managing male-factor problems, and delivering assisted reproductive technology (ART).
Candidates sometimes assume the subspecialty is mostly in vitro fertilization. In reality, the endocrine foundation carries enormous weight, and a large portion of the blueprint concerns physiology, assays, and endocrine disease rather than laboratory procedures.
What an REI Subspecialist Actually Does
The clinical scope extends well beyond fertility treatment. According to the ASRM scope-of-practice statement on the REI subspecialist, the field spans reproductive endocrine disorders, infertility evaluation and treatment, and fertility preservation. In day-to-day practice that translates into several recognizable patterns:
- Diagnosing and managing ovarian and adrenal disorders, neuroendocrine problems, and thyroid disease as they affect reproduction.
- Evaluating abnormal uterine bleeding and endometrial physiology.
- Working up recurrent pregnancy loss and managing early pregnancy complications.
- Treating anatomic disease such as endometriosis, adenomyosis, fibroids, polyps, adhesions, congenital tract anomalies, and Asherman syndrome.
- Counseling on genetic screening and testing and applying results to patient care.
- Preserving fertility for patients facing gonadotoxic treatment or other threats to reproductive potential.
The Training Path Behind the Acronym
The ASRM 2025 scope-of-practice statement describes the standard route into the subspecialty: medical school, a four-year obstetrics and gynecology residency, and then a three-year REI fellowship. That professional-society summary describes training context; it is not an ABOG exam blueprint, and the two should not be conflated.
| Stage | Duration | What it provides |
|---|---|---|
| Medical school | Standard medical degree program | Foundation in medicine |
| Ob/Gyn residency | Four years | General obstetrics and gynecology training |
| REI fellowship | Three years | Subspecialty clinical and research training |
| ABOG subspecialty certification | QE (written), then CE (oral) | Board certification in REI |
For a deeper treatment of who qualifies to sit for the examinations, see our guide to REI requirements, eligibility, and prerequisites, and for a view of what fellowship preparation looks like, REI training is a useful companion.
The Six Content Domains Under the Label
ABOG's currently linked REI blueprint organizes the subspecialty into six primary clinical categories and 27 subcategories. The document does not print percentage weights, and it does not allocate content separately between the written and oral stages. Treat the six domains below as a map of scope rather than a weighted pie chart. Our full walk-through is in REI Exam Domains 2026: Complete Guide to All 6 Content Areas.
Domain 1: Foundational Reproductive Endocrinology
The science underneath everything else.
- Hormone structure and function (REI1.1)
- Basic pharmacology (REI1.2)
- Laboratory assays (REI1.3)
Domain 2: Reproductive Endocrine Function and Disease
Normal and disordered endocrine physiology across a woman's life.
- Reproductive physiology across the lifespan (REI2.1)
- Neuroendocrine disorders (REI2.2) and thyroid disorders (REI2.3)
- Endometrial physiology and abnormal uterine bleeding (REI2.4)
- Ovarian and adrenal disorders, idiopathic and iatrogenic (REI2.5)
Domain 3: Conception and Pregnancy: Physiology and Pathology
From gametes to early gestation.
- Gamete biology (REI3.1) and early embryo development (REI3.2)
- Endocrinology of pregnancy (REI3.3)
- Early pregnancy (REI3.4) and recurrent pregnancy loss (REI3.5)
Domain 4: Fertility and Infertility
The clinical core most people associate with the specialty.
- Female fertility and infertility (REI4.1) and male infertility (REI4.2)
- Fertility treatment: special considerations (REI4.3)
- Assisted reproductive technology techniques (REI4.4)
- Fertility preservation (REI4.5)
Domain 5: Anatomic Reproductive Disorders
Structural disease that affects fertility and pelvic health.
- Pelvic adhesive disease (REI5.1), endometriosis (REI5.2), adenomyosis (REI5.3)
- Congenital anomalies of the reproductive tract (REI5.4)
- Asherman syndrome (REI5.5), leiomyomas (REI5.6), endometrial polyps (REI5.7)
Domain 6: Reproductive Genetics
Both understanding and applying genetic information.
- Understanding of genetic testing and screening (REI6.1)
- Application of genetic screening and testing to patient care (REI6.2)
The Two-Stage ABOG Exam
REI certification is not a single sitting. It retains a written Qualifying Examination (QE), delivered through Pearson VUE, and an oral Certifying Examination (CE). They are different experiences testing the same body of knowledge in different ways, and the credential should not be renamed to either stage alone.
| Feature | Qualifying Examination (QE) | Certifying Examination (CE) |
|---|---|---|
| Format | Written, computer-based | Oral |
| Delivery | Pearson VUE | Conducted by ABOG |
| Tests | Breadth of knowledge across the blueprint | Clinical reasoning and judgment under questioning |
| Blueprint allocation | Not separately weighted in the common blueprint | Not separately weighted in the common blueprint |
One recent policy change matters for anyone finishing fellowship now. According to ABOG's 2026 update to subspecialty program directors, the thesis moves from CE eligibility to QE eligibility for fellowship graduates from 2026 onward. Earlier graduates retain their prior requirements. Always confirm current details in the applicable QE or CE bulletin, because stage-specific numeric logistics such as question counts and timing are not established by the common blueprint.
The same presentation lists 2026 dates for reference: the subspecialty QE on July 20 and the CE during April 13-17. Those are historical 2026 dates, not an invitation to book. For scheduling mechanics, see REI exam dates, testing windows, and deadlines; for fees, REI certification cost; and for scoring, REI passing score.
Key Takeaway
Prepare for two different skills. The QE rewards broad recall across all six domains; the CE rewards the ability to reason aloud through a patient scenario. Practice questions build the first skill, and talking through cases with a colleague builds the second.
What the 2025 Outcome Data Say
The ABOG update to program directors reports a 2025 REI first-time QE pass rate of 100% (N=55) and a CE pass rate of 94.7% (N=57). The presentation's QE repeat and overall cohort counts are internally inconsistent, so we do not assert a reconciled overall rate. Small cohorts also mean these figures can swing sharply from year to year. For context on how to read them, see REI pass rate: what the data shows and how hard the REI exam is.
High pass rates do not mean the content is easy. Candidates reaching this stage have already passed Ob/Gyn boards, completed demanding fellowships, and been selected through a competitive process. The examinations are calibrated against a highly prepared group.
Where REI Subspecialists Work
Certification opens several practice settings. Without inventing figures, the common employers and structures include:
- Private fertility practices and networks offering evaluation, ovulation induction, intrauterine insemination, and IVF.
- Academic medical centers combining clinical care, fellowship teaching, and research.
- Hospital-affiliated reproductive medicine programs serving both fertility and endocrine patients.
- Fertility preservation programs coordinating with oncology and other services.
Compensation and job-market questions deserve their own treatment: our REI salary guide, the analysis of whether REI certification is worth it, and a look at REI jobs take those up directly.
Sequencing Your Preparation by Domain
General study habits matter less than ordering the content sensibly. The domains build on each other, so a logical sequence runs from foundations outward to clinical application.
Foundations (Domain 1)
- Hormone structure, receptor pharmacology, and assay interpretation come first because every later domain assumes them.
Endocrine disease (Domain 2)
- Layer thyroid, neuroendocrine, adrenal, ovarian, and bleeding disorders onto the physiology you just reviewed.
Conception through early pregnancy (Domain 3)
- Gamete biology, embryo development, pregnancy endocrinology, and recurrent loss.
Clinical infertility and anatomy (Domains 4 and 5)
- Pair ART techniques and male factor with structural disease, since both drive treatment decisions.
Genetics and integration (Domain 6)
- Finish with genetic testing, then cycle through mixed practice that crosses domains.
When you are ready for full coverage, work through our REI study guide, keep the REI cheat sheet nearby for last-minute review, and test your recall with the REI practice test bank. Remember that any practice-question allocation across domains is editorial rather than an official weighting, so use it for balanced coverage, not for predicting emphasis. You can also start from the main REI Exam Prep site to browse available question sets, and read the overview of REI certification if you are still deciding whether to pursue it.
Frequently Asked Questions
REI stands for Reproductive Endocrinology & Infertility, a subspecialty of obstetrics and gynecology certified through the American Board of Obstetrics and Gynecology (ABOG). It covers reproductive hormones, infertility evaluation and treatment, and related anatomic and genetic conditions.
Not exactly. IVF and other ART techniques are one part of the specialty, but REI also covers endocrine disorders, early pregnancy, recurrent loss, anatomic disease, fertility preservation, and genetics. Many patients see an REI subspecialist for conditions that never lead to IVF.
The current blueprint lists six primary categories and 27 subcategories. It does not print percentage weights and does not assign separate coverage to the written and oral stages, so treat the domains as a scope map rather than a weighted breakdown.
Certification involves two stages: a written Qualifying Examination (QE) delivered through Pearson VUE and an oral Certifying Examination (CE). They are distinct, and the credential should not be described as only one of them.
According to the ASRM 2025 scope-of-practice statement, the path runs through medical school, a four-year obstetrics and gynecology residency, and a three-year REI fellowship, followed by the ABOG certification process.